Nicholas Borotto

My research program strives to improve mass spectrometric-based detection and analysis of biomolecules. In particular, we pair mass spectrometry with chemical derivatization, photon irradiation, ion mobility, and radical chemistry to elucidate the three-dimensional structure of proteins, better characterize the acidic and hydrophobic proteome, detect and localize post-translational modifications. Centered at the interface of chemistry and biology, my research program provides students with the opportunity to tackle both biochemically-focused projects and biophysical questions at the core of the techniques themselves. Currently, my group is recruiting students for three projects:

1) Equipping a carbon monoxide laser to a mass spectrometer, characterizing the behavior of irradiated biomolecules, and applying infrared multiphoton dissociation (IRMPD) to instruments and at pressure regimes traditionally precluded from this technique.

2) Probing protein three-dimensional structure with photocaged small molecule reagents both in vitro and in vivo and demonstrating the utility of the temporal and spatial control that is provided by these probes.

3) Applying the tandem mass spectrometry technique free-radical initiated peptide sequencing (FRIPS) to complex mixtures of anions.

M. Rashed Khan

Khan Lab@UNR aims to study, design, and develop soft materials, unconventional processes, and reconfigurable micro/nanodevices that can be harnessed and optimized further for advanced biochemical, biomedical, and physicochemical applications. The lab is also keen to establish a multidisciplinary smart-manufacturing research group, including researchers from various backgrounds. Through short and long-term active collaboration, Khan Lab@UNR would like to address fundamental challenges associated with soft micro-device fabrication, 3D/4D (bio)printing, and patterning, advanced hybrid sensor manufacturing, biomedical device development – which are still unnoticed and under-explored, and need further investigation.

Additionally, our group also focuses on computational neuroscience and neurobioengineering. Under this research direction, we study human brain, brain functions, brain structure so that the established knowledge can be broadly applicable to general biomecical science and knowledge of the brain and brain-diseases.