The mission of the laboratory is decipher how these novel RNA molecules are regulated and identify their physiological roles in cells. The biological roles of extended 3’UTRs and circular RNAs remain for the most part unexplored. We are particularly interested in how these RNAs might be involved in neurological disease and during aging.
Projects in the lab include the use of Drosophila, mice and mammalian cell culture. High-throughput, genome-wide sequencing approaches will employed. Exciting new genome editing approaches (CRISPR/CAS) will be exploited to understand the functional roles in vivo of non-coding RNAs.